Underline indicates current/former mentee
* indicates joint first authorship
2025
Preprints / In Press
Sanders F, Baltramonaityte V, Lussier AA, Smith ADAC, Dunn EC, Walton E. Home and
Epigenome: DNA Methylation as a Link Between Poor Housing Quality and Depressive
Symptoms. medRxiv. Submitted.
McKenna BG, Lussier AA, Suderman MJ, Walton E, Simpkin AJ, Hüls A, Dunn EC.
Strengthening rigor and reproducibility in epigenome-wide association studies of social
exposures and brain-based health outcomes. Current Environmental Health Reports.
2024
Lussier AA*, Smith BJ* , Fischer J, Luo M, Cerutti J, Schneper L, Cecil CAM, Felix JF, Mitchell C, Notterman DA, Ressler KJ, Schaid DJ, Simpkin AJ, Suderman MJ, Walton E, Smith ADAC, Dunn EC. DNA methylation mediates the link between adversity and depressive symptoms. Nature Mental Health. PDF. Supplemental materials.
Lussier AA & Dunn EC. Research Briefing: Childhood adversity may cause epigenetic changes that protect against or increase depression risk. Nature Mental Health.PDF.
Lussier AA, Schuurmans IK, Großbach A, MacIsaac J, Dever K, Koen N, Zar HJ, Stein DJ, Kobor MS, Dunn EC. Technical variability across the 450K, EPICv1, and EPICv2 DNA methylation arrays: Lessons learned for clinical and longitudinal studies. Clinical Epigenetics. PDF.
Baltramonaityte V, Lussier AA, Smith ADAC, Simpkin AJ, Fairchild G, Dunn EC, Walton E. Stress reactivity moderates the association between stressful life events and depressive symptoms in adolescents: Results from a population-based study. Journal of Affective Disorders. PDF.
BGroßbach A, Suderman MJ, Hüls A, Lussier AA, Smith ADAC, Walton E, Dunn EC, Simpkin AJ. Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance. Clinical Epigenetics. PDF.
Sanders F, Lussier AA, Walton E. Are housing circumstances associated with faster epigenetic ageing?: a commentary on Clair et al. Journal of Epidemiology and Community Health. PDF.
Schuurmans IK, Dunn EC, Lussier AA. DNA methylation as a possible causal mechanism linking childhood adversity and health: Results from two-sample mendelian randomization study. American Journal of Epidemiology. PDF. Supplemental materials.
2023
Lussier AA, Zhu Y, Smith BJ, Cerutti J, Fisher J, Melton P; Wood NM, Cohen-Woods S, Huang RC, Mitchell C, Schneper L, Notterman DA, Simpkin AJ, Smith ADAC, Suderman MJ, Walton E, Relton CL, Ressler KJ, Dunn EC. Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort. Lancet Child and Adolescent Health. PDF. Supplemental Materials.
Liu J*, Cerutti J*, Lussier AA, Zhu Y, Simpkin AJ, Smith ADAC, Dunn EC. Socioeconomic changes predict genome-wide DNA methylation in childhood. Human Molecular Genetics. PDF. Supplemental Materials. Supplemental Tables.
Lussier AA, Weinberg J. Ethical Considerations for Biomarkers of Fetal Alcohol Spectrum Disorder and Other Neurodevelopmental Disorders. In: Gibbard B (ed) Developments in Neuroethics and Bioethics, Volume 6. Elsevier. 2023. PDF.
Lussier AA, Petrelli B, Hicks GG, Weinberg J. Genetic, Epigenetic, and Environmental Influences on Fetal Alcohol Spectrum Disorder: Implications for Diagnosis, Research, and Clinical Practice. In: Eisenstat DD, Goldowitz D, Oberlander TF, Yager JY (eds) Neurodevelopmental Pediatrics: Genetic and Environmental Influences. Springer. 2023. PDF.
2022
Lussier AA, Zhu Y, Smith BJ, Simpkin AJ, Smith ADAC, Suderman MJ, Walton E, Relton CL, Ressler KJ, Dunn EC. Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study. Biological Psychiatry: Global Open Science. PDF.
Zhu Y, Lussier AA, Smith ADAC, Simpkin AJ, Suderman M, Walton E, Relton C, Dunn EC. Examining the epigenetic mechanism of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology. PDF. Supplemental Materials. Supplemental Tables.
Lussier AA, Zhu Y, Smith BJ, Simpkin AJ, Smith ADAC, Suderman MJ, Walton E, Ressler KJ, Dunn EC. Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies. Epigenetics. PDF. Supplemental Materials. Supplemental Tables.
2021
Cerutti J, Lussier AA, Zhu Y, Liu J, Dunn EC. Associations between indicators of socioeconomic position and DNA methylation: A scoping review. Clinical Epigenetics. PDF. Supplemental Materials. Supplemental Tables.
Lussier AA*, Bodnar TS*, Weinberg J. Intersection of epigenetic and immune alterations: Implications for Fetal Alcohol Spectrum Disorder and mental health. Frontiers in Neuroscience. PDF.
Lussier AA, Bodnar TS, Moksa M, Hirst M, Kobor MS, Weinberg J. Prenatal adversity alters the epigenetic profile of the prefrontal cortex: Sexually dimorphic effects of prenatal alcohol exposure and food-related stress. Genes. PDF. Supplemental Materials.
Gatev E, Inkster AM, Konwar C, Negri GL, Lussier AA, Skakkebaek A, Sokolowski MB, Gravholt CH, Dunn EC, Kobor MS, Aristizabal MJ. Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation. Nucleic Acids Research. PDF. Supplemental Materials. Supplemental Tables.
Zhu Y, Wang MJ, Crawford KM, Ramírez-TapiaJC, Lussier AA, Davis KA, de Leeuw C, Takesian AE, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Hensch TK, Smoller JW, Dunn EC. Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression. Neuropsychophamacology. PDF. Supplemental Materials. Supplemental Tables.
Mountain RV*, Zhu Y*, Pickett OR, Lussier AA, Goldstein JM, Roffman JL, Bidlack FB, Dunn EC. Shed teeth record children’s exposure to maternal psychosocial stress and social support during the prenatal and perinatal periods: Results from a prospective cohort study. JAMA Network Open. PDF. Supplemental Materials.
Glickman EA, Choi KW, Lussier AA, Smith BJ, Dunn EC. Childhood emotional neglect and adolescent depression: Assessing the protective role of peer social support in a longitudinal birth cohort. Frontiers in Psychiatry. PDF. Supplemental Materials.
2020
Lussier AA, Hawrilenko M, Wang MJ, Choi K, Cerutti J, Zhu Y, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dunn EC. Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms in childhood and adolescence. Journal of Child Psychology and Psychiatry. PDF. Supplemental Materials.
Zhu Y, Simpkin AJ, Suderman MJ, Lussier AA, Walton E, Dunn EC, Smith ADAC. A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context. American Journal of Epidemiology. PDF. Supplemental Materials.
Schaffner SL, Lussier AA, Baker JA, Goldowitz D, Hamre KM, Kobor MS. Epigenetic, transcriptional, and apoptotic responses to neonatal alcohol exposure in mice are influenced by sex and brain region. Frontiers in Genetics. PDF. Supplemental Materials.
2019
Brown P, RELISH Consortium, Zhou Y. Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database.
Raj SM, Lussier AA. Molecular and Epigenetic Clocks of Aging. In: Gu D, Dupre M (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. 2019. PDF.
2018
Lussier AA, Bodnar TS, Mingay M, Morin AM, Hirst M, Weinberg J, Kobor MS. Prenatal alcohol exposure: profiling developmental DNA methylation patterns in central and peripheral tissues. Frontiers in Genetics. PDF. Supplemental Materials. Supplemental Tables.
Islam SA, Lussier AA, Kobor MS. Epigenetic analysis of human postmortem brain. The Handbook of Clinical Neurology. PDF.
Lussier AA, MacIsaac JL, Morin AM, Salmon J, Weinberg J, Reynolds J, Pavlidis P, Chudley AE, Kobor MS. DNA methylation as a predictor of fetal alcohol spectrum disorder. Clinical Epigenetics. PDF. Supplemental Materials. Supplemental Tables.
Lussier AA, Keinan A. Crowdsourced genealogies and genomes. Science. PDF.
Lussier AA, Islam SA, Kobor MS. Genetics and epigenetics of development. In Gibbs R. & Kolb B. (Eds.). The Neurobiology of Brain and Behavioral Development. Elsevier Inc. PDF.
2017
Lussier AA, Weinberg J, Kobor MS. Epigenetics studies of fetal alcohol spectrum disorder: where are we now? Epigenomics. PDF.
2016
Portales-Casamar E*, Lussier AA*, Jones MS, MacIsaac JL, Edgar R, Mah SM, Barhdadi A, Provost S, Lemieux-Perreault LP, Chudley AE, Dubé MP, Reynolds J, Pavlidis P, Kobor MS. DNA methylation signature of human fetal alcohol spectrum disorder. Epigenetics & Chromatin. PDF. Supplemental Materials.
2015
Lussier AA, Stepien KS, Weinberg J, Kobor MS. Prenatal alcohol exposure alters gene expression in the rat brain: experimental design and bioinformatic analysis of microarray data. Data in Brief. PDF. Supplemental Materials.
Fonseca BD, Zakaria C, Jia JJ, Svitkin Y, Tahmasebi S, Healy D, Hoang HD, Jensen JM, Diao IT, Lussier AA, Dajadian C, Wang W, Matta-Camacho E, Hearnden J, Smith EM, Tsukumo Y, Yanagiya A, Morita M, Petroulakis E, González JL, Hernández G, Alain T, Damgaard CK. Lupus autoantigen related protein 1 (LARP1) is a key repressor of terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1). Journal of Biological Chemistry. PDF. Supplemental Materials.
Lussier AA*, Stepien KS*, Neumann SM, Pavlidis P, Kobor MS, Weinberg J. Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain. Alcoholism: Clinical and Experimental Research. PDF. Supplemental Materials.
2014
Goldowitz D*, Lussier AA*, Boyle J*, Wong K, Lattimer S, Lu L, Kobor MS, Hamre KH. Molecular mechanisms underlying ethanol-induced neurodegeneration. Frontiers in Genetics. PDF.
The Lussier Lab 